| 陈莉莉 陈晓勇 祝佩 王巧.养血安胎方对复发性流产患者子宫内膜容受性、性激素及血栓前状态的影响[J].江西中医药大学学报,2026,38(1):27-30. |
| 养血安胎方对复发性流产患者子宫内膜容受性、性激素及血栓前状态的影响 |
| Effect of Yangxue Antai Prescription on Endometrium Receptivity,Sex Hormone and Pre-thrombotic State in Patients with Recurrent Abortion |
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| DOI：10.20140/j.2095-7785.2026.01.07 |
| 中文关键词: 复发性流产；养血安胎方；子宫内膜容受性；性激素；血栓前状态 |
| 英文关键词: Recurrent Abortion;Yangxue Antai Prescription; Endometrial Receptivity; Sex Hormone; Prethrombotic State |
| 基金项目:国家中医药管理局第七批名老中医药专家学术经验继承工作项目（国中医药人教函[2022]76 号）；江西省中医药管理局科技计划项目
（2024B0813）。 |
| 作者 | 单位 | | 陈莉莉 陈晓勇 祝佩 王巧 | 江西省妇幼保健院中医科 / 江西省中西医结合女性生殖重点研究
室 南昌 330006 |
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| 中文摘要: |
| 目的：探讨养血安胎方对复发性流产患者子宫内膜容受性、性激素及血栓前状态的影响。方法：选取2021 年5 月—
2023 年1 月江西省妇幼保健院收治的68 例复发性流产患者，按照随机数字表法分为对照组（34 例）与观察组（34 例），对
照组患者采用西药治疗，观察组在对照组基础上采用养血安胎方治疗，均持续治疗至妊娠12 周，随访至妊娠结束并记录妊
娠结局。分别于治疗前后，比较2 组患者的子宫内膜容受性、性激素水平、凝血指标及纤溶指标。结果：治疗后，观察组患
者的存活率（88 .24%），高于对照组（67 .65%）（P<0 .05）；2 组患者子宫内膜厚度增加，动脉血流阻力指数（RI）、搏动指数
（PI）均降低，且观察组均优于对照组（P<0 .05）；2 组患者雌激素（E2）、孕酮（P）及血人绒毛促性腺激素（HCG）水平均
升高，且观察组均高于对照组（P<0 .05）；2 组患者凝血活酶时间（aPTT）、凝血酶原时间（PT）及凝血酶时间（TT）均升高，
且观察组均高于对照组（P<0 .05）；2 组患者纤维蛋白原（Fbg）、D 二聚体（D-D）水平均降低，抗凝血酶（AT）水平升高，
且观察组均优于对照组（P<0 .05）。结论：养血安胎方能够增强复发性流产患者子宫内膜容受性，升高性激素水平，改善患
者血栓前状态。 |
| 英文摘要: |
| Objective: To investigate the effects of Yangxue Antai Prescription on endometrial receptivity, sex hormones and pre
thrombotic status in patients with recurrent abortion. Methods: A total of 68 patients with Jiangxi Maternal and Child Health Hospital from
May 2021 to January 2023 were selected and divided into the conventional group (34 cases) and the study group (34 cases) according to
random number table method. The conventional group was treated with western medicine, while the study group was treated with Yangxue
Antai Prescription on the basis of the conventional group, and the treatment lasted until 12 weeks of gestation. Follow-up until the end
of pregnancy and pregnancy outcomes were recorded. Endometrial receptivity, sex hormone levels, coagulation indexes and fibrinolysis
indexes were compared before and after treatment. Results: The survival rate of the study group was 88.24%, which was significantly higher
than that of the conventional group (67.65%) (P<0.05). After treatment, endometrial thickness increased, and artery resistance index(RI)
and pulsation index(PI) decreased in both groups, and the study group was higher than the conventional group (P<0.05). Estrogen (E2),
progesterone (P) and Human chorionic gonadotropin (HCG) levels in two groups were increased, and the levels in study group were higher
than those in conventional group (P<0.05). Activated partial thromboplastin time (aPTT), prothrombin time (PT) and thrombin time (TT)
increased in both groups.The study group was higher than the conventional group (P<0.05).The levels of fibrinogen (Fbg) and D-Dimer (D
D) were decreased in both groups, and antithrombin (AT) was elevated, which was higher in the study group than in the conventional group
(P<0.05). Conclusion: Yangxue Antuan Prescription can enhance endometrial receptivity, increase sex hormone level and improve the pre
thrombotic state of patients with recurrent abortion. |
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