| 罗涛 张先艳 张庚华 殷鹭 宋永贵 罗小泉 曾财花 .生、酒五味子对慢性失眠诱导的抑郁样行为及胃组织炎症的改善作用[J].江西中医药大学学报,2025,37(5):83-86. |
| 生、酒五味子对慢性失眠诱导的抑郁样行为及胃组织炎症的改善作用 |
| Improvement Effects of Raw and Wine-processed Schisandra Chinensis Fructus on Chronic Insomnia-induced Depressive-like Behaviors and Gastric Tissue Inflammation |
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| DOI：10.20140/j.2095-7785.2025.05.20 |
| 中文关键词: 五味子；酒制；抑郁症；失眠；炎症 |
| 英文关键词: Schisandra Chinensis Fructus; Wine Processing; Depression; Insomnia; Inflammation |
| 基金项目:江西省中医药管理局科技项目（2022B1069）；江西中医药大学教学改革项目（2021jzyb-26）。 |
| 作者 | 单位 | | 罗涛 1 张先艳 1 张庚华 1 殷鹭 1 宋永贵 2 罗小泉 2 曾财花 1 | 1. 南昌大学第一附属医院 南
昌 330006 ；2. 江西中医药大学 南昌 330004 |
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| 中文摘要: |
| 目的：探究生、酒五味子对慢性失眠诱导的抑郁样行为及胃组织炎症的改善作用。方法：采用实验室建立睡眠剥夺
结合光照诱导抑郁模型，然后给予生、酒五味子提取液进行干预，检测神经行为学（悬尾实验、强迫游泳实验），并进行胃组
织切片实验及胃组织中炎症指标的检测。评价生、酒五味子对小鼠抑郁样行为及胃组织炎症的影响。结果：生、酒五味子能
够改善小鼠的抑郁样行为，修复胃组织细胞形态，且改善胃组织炎症。结论：生、酒五味子通过抑制胃组织炎症反应改善慢
性失眠诱导的抑郁样行为。 |
| 英文摘要: |
| Objective: To explore the improvement effects of raw and wine-processed Schisandra Chinensis Fructus on depression-like
behaviors induced by chronic insomnia and gastric tissue inflammation. Methods: A depression model was induced by sleep deprivation
combined with light exposure established in the laboratory. Then, the mice were intervened with extracts of raw and wine-processed
Schisandra Chinensis Fructus. Neurobehavioral tests (tail suspension test, forced swimming test) were conducted, and gastric tissue section
experiments and detection of inflammatory indicators in gastric tissues were carried out. The effects of raw and wine-processed Schisandra
Chinensis Fructus on depression-like behaviors and gastric tissue inflammation in mice were evaluated. Results: Both raw and wineprocessed Schisandra Chinensis Fructus could improve depression-like behaviors in mice, repair the morphological structure of gastric
tissue cells, and alleviate gastric tissue inflammation. Conclusion: Raw and wine-processed Schisandra Chinensis Fructus can improve
depression-like behaviors induced by chronic insomnia by inhibiting the inflammatory response in gastric tissues. |
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