欢迎访问《江西中医药大学学报》编辑部网站！

文章摘要

周建华周昀璐俞春英刘德强钱丽萍吴胜王训立黄镇 .基于福建黄兔温病气分证发热模型比较不同类型中药注射液的退热效果[J].江西中医药大学学报,2025,37(5):77-82/86.

基于福建黄兔温病气分证发热模型比较不同类型中药注射液的退热效果

Comparison of the Antipyretic Effects of Different Types of Traditional Chinese Medicine Injections Based on a Febrile Model of Wenbing Qifen Syndrome in Fujian Yellow Rabbits

DOI：10.20140/j.2095-7785.2025.05.19

中文关键词: 福建黄兔；温病气分证；动物发热模型；中药注射液；退热效果

英文关键词: Fujian Yellow Rabbits; Wenbing Qifen Syndrome; Animal febrile model; Traditional Chinese Medicine Injection; Antipyretic Effect

基金项目:福建省“雏鹰计划”青年拔尖人才计划项目（闽人社文［2023］142 号）；福建自然科学基金面上项目（2024J01743）；福建中医药大学青年科技创新培育计划项目（XQC2024003）。

作者	单位
周建华 ¹ 周昀璐 ² 俞春英 ¹ 刘德强 ¹ 钱丽萍 ³ 吴胜 ³ 王训立 ¹ 黄镇 ^1,4	1. 福建中医药大学实验动物中心福州 350122；2. 浙江中医药大学杭州 310053；3. 福建省医学科学研究院动物实验中心福州 350001；4. 闽港澳台中医药传承创新合作实验室福州 350122

摘要点击次数: 113

全文下载次数: 109

中文摘要:

目的：比较不同类型中药注射液对温病气分证福建黄兔发热模型的退热效果。方法：利用大肠杆菌内毒素注射构建温病气分证福建黄兔发热模型，将造模成功的福建黄兔随机分为模型组、中药干预组（清热开窍组、清热解毒组、清脏腑热组、辛凉解表组）与西药干预组，在注射内毒素 20 min 后给予相应药物退热，观察福建黄兔体征并进行测温和数据分析。结果：模型组在造模后，体温净增值达（2.01 ± 0.41）℃ , 体温升高超过 1 ℃以上的发热时长达 4.00（3.55，4.45）h ，并呈现倦怠少动、呼吸加快。4 种中药干预组的体温净增值及发热时长数据相互比较显示，辛凉解表组退热效果最好；其次是清热解毒组；再次为清热开窍组；最后为清脏腑热组。单个中药注射液比较中，穿琥宁和柴胡注射液净增值极显著下降，且二者与双黄连注射液都能将升温控制在 1 ℃以下。结论：不同类型中药注射液对于温病气分证福建黄兔发热模型均能有效抑制升温，缩短发热时长，起到退热效果。运用清热解毒类和辛凉解表类的中药注射液对于温病气分证模型的退热效果更佳。

英文摘要:

Objective: To compare the antipyretic effects of different types of traditional Chinese medicine (TCM) injections on the febrile model of Wenbing Qifen Syndrome (disease caused by pathogenic heat) in Fujian yellow rabbits. Methods: The febrile model of Wenbing Qifen Syndrome was established in Fujian yellow rabbits by injecting Escherichia coli lipopolysaccharide (LPS). The successfully modeled rabbits were randomly divided into a model group, TCM intervention groups (Qingre Kaitiao group, Qingre Jiedu group, Qing Zangfu Re group, Xinliang Jiebiao group), and a Western medicine intervention group. Twenty minutes after LPS injection, the respective antipyretic agents were administered. The rabbits' clinical signs were observed, and body temperatures were monitored and analyzed. Results: After modeling, the model group showed a temperature increase of more than (2.01 ± 0.41) ℃, fever with an increase in temperature of more than 1 ℃ for up to 4.00 (3.55, 4.45) h, accompanied by lethargy and increased respiratory rate. Comparisons of the TCM intervention groups showed that the Xinliang Jiebiao group had the best antipyretic effect, followed by the Qingre Jiedu group, then the Qingre Kaitiao group, with the Qing Zangfu Re group being the least effective. Among the individual TCM injections, Chuanhuning and Chaihu injections significantly reduced the net temperature increase, with both controlling the temperature rise within 1 ℃, along with Shuanghuanglian injection. Conclusion: Different types of TCM injections effectively reduced the temperature increase and shortened the fever duration in the Wenbing Qifen Syndrome febrile model in Fujian yellow rabbits. Qingre Jiedu and Xinliang Jiebiao TCM injections demonstrated superior antipyretic effects in this model.

查看全文查看/发表评论下载PDF阅读器

关闭