| 王依蕾 冯艳 李志峰 陈道峰 冯育林 钟国跃 .不同基原藏药叶格兴植物化学成分及体外抗炎、抗氧化活性研究[J].江西中医药大学学报,2025,37(5):56-64. |
| 不同基原藏药叶格兴植物化学成分及体外抗炎、抗氧化活性研究 |
| Anti-inflammatory, Antioxidant and Chemical Component Research of Different Base-origin Tibetan Medicines Yegexing in Vitro |
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| DOI：10.20140/j.2095-7785.2025.05.16 |
| 中文关键词: 藏药叶格兴；差异化学成分；抗炎；抗氧化 |
| 英文关键词: Tibetan Medicine Yegexing; Differential Chemical Component; Anti-inflammatory; Antioxidant |
| 基金项目:中央引导地方科技发展项目（20221ZDD02007）；国家重点研发计划项目（2019YFC1712302，2019YFC1712304）。 |
| 作者 | 单位 | | 王依蕾 1 冯艳 1 李志峰 2 陈道峰 3 冯育林 2 钟国跃 2 | 1. 江西中医药大学 南昌 330004；2. 中
药固体制剂制造技术国家工程研究中心 南昌 330006；3. 复旦大学药学院 上海 200433 |
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| 中文摘要: |
| 目的：研究不同基原藏药叶格兴的化学成分以及抗炎、抗氧化活性差异。方法：采用超高效液相色谱与飞行时间质
谱联用技术对菊状千里光等 7 种不同基原叶格兴醇提物进行化学成分分析，筛选出不同基原叶格兴之间差异化学成分，同时
对不同基原叶格兴抗炎活性及其相应差异化学成分相关性进行研究，并比较了 7 种基原叶格兴抗氧化活性强弱。结果：共鉴
定出 151 个差异化学成分，7 种基原叶格兴均具有显著抗炎作用。除柳叶菜风毛菊外，不同基原藏药叶格兴 70% 醇提物对
DPPH 自由基具有清除作用。结论：不同基原叶格兴抗炎、抗氧化活性及化学成分也有所差异，为进一步完善不同基原质量
标准提供参考。 |
| 英文摘要: |
| To study the differences in chemical component, anti-inflammatory and antioxidant activities of Tibetan Medicines
Yegexing. Methods: Ultra high performance liquid tandem chromatography quadrupole time of flight mass spectrometry was used to analyze
the chemical component of alcohol extracts of Ye Gexing, and select the different chemical components of Yegexing of different origins.
Meanwhile, the anti-inflammatory activities of different origins and their different chemical components were studied. And the antioxidant
activities of Yegexing was compared. Results: A total of 151 different chemical components were identified, Yegexing had significant
anti-inflammatory effects. Except for Saussuria salicifolia, the alcohol extracts of Yegexing had scavenging effect on DPPH free radicals.
Conclusion: There are differences in anti-inflammatory, antioxidant activities and chemical component of different Yegexing, which can
provide reference for further improvement of quality standards of different Yegexing. |
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