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易军艾博华严张仁王万春毛文丽王建刚徐亨浪张乃忻 .五苓散联合盐酸坦索罗辛治疗脾肾阳虚型良性前列腺增生症临床观察[J].江西中医药大学学报,2025,37(5):29-32.

五苓散联合盐酸坦索罗辛治疗脾肾阳虚型良性前列腺增生症临床观察

Clinical Efficacy of Wuling Powder Combined with Tamsulosin Hydrochloride Sustained-release Capsule in the Treatment of Benign Prostatic Hyperplasia (Spleen-kidney Yang Deficiency Type)

DOI：10.20140/j.2095-7785.2025.05.09

中文关键词: 五苓散；盐酸坦索罗辛；脾肾阳虚证；前列腺增生症；残余尿量

英文关键词: Wuling Powder; Tamsulosin Hydrochloride Sustained-release Capsules; Spleen-kidney Yang Deficiency Type; Benign Prostatic Hyperplasia; Residual Urine Volume

基金项目:江西省中医药管理局科技计划项目（2023B0191）

作者	单位
易军 ¹ 艾博华 ² 严张仁 ¹ 王万春 ¹ 毛文丽 ¹ 王建刚 ¹ 徐亨浪 ¹ 张乃忻 ¹	1. 江西中医药大学附属医院南昌 330006；2. 江西中医药大学研究生院南昌 330004

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中文摘要:

目的：探究五苓散联合盐酸坦索罗辛缓释胶囊治疗脾肾阳虚型良性前列腺增生症（BPH）的临床疗效。方法：选取江西中医药大学附属医院男科门诊诊治的脾肾阳虚型 BPH 患者 60 例，以随机数字表法均分为 3 组，各 20 例。A 组予以五苓散联合盐酸坦索罗辛缓释胶囊治疗，B 组予盐酸坦索罗辛缓释胶囊治疗，C 组单用五苓散治疗，3 组均治疗 8 周。比较 3 组治疗前后的国际前列腺症状评分（IPSS）、生活质量评分（QoL）、最大尿流率（Qmax）、中医证候评分、前列腺体积（PV）、排尿后残余尿量（PVR）等。结果：A 组总有效率为 90.00%，优于 B 组的 65.00% 与 C 组的 70.00%，差异具有统计学意义（P<0.05）。3 组的 IPSS、QoL、中医证候评分及 PV、PVR 均较治疗前降低，Qmax 值较治疗前升高，其中 A 组的 IPSS、QoL、中医证候评分及 PVR 值均低于 B、C 组，Qmax 值高于 B、C 组，差异均有统计学意义（P<0.05）。结论：五苓散联合盐酸坦索罗辛缓释胶囊治疗脾肾阳虚型 BPH 疗效显著，可为临床治疗该病提供参考。

英文摘要:

Objective: To explore the clinical efficacy of Wuling Powder combined with Tamsulosin Hydrochloride Sustained-Release Capsules in the treatment of benign prostatic hyperplasia (BPH) of Spleen-Kidney Yang Deficiency Type. Methods: A total of 60 patients with BPH of Spleen-Kidney Yang Deficiency Type treated in the Andrology Outpatient Department of the Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine were selected. They were equally divided into 3 groups using a random number table, with 20 patients in each group. Group A was treated with Wuling Powder combined with Tamsulosin Hydrochloride Sustained-Release Capsules; Group B was treated with Tamsulosin Hydrochloride Sustained-Release Capsules alone; Group C was treated with Wuling Powder alone. All 3 groups received treatment for 8 weeks. The International Prostate Symptom Score (IPSS), Quality of Life Score (QoL), maximum urinary flow rate (Qmax), TCM Syndrome Score, prostate volume (PV), and post-void residual urine volume (PVR) were compared among the 3 groups before and after treatment. Results: The total effective rate of Group A was 90.00%, which was superior to 65.00% of Group B and 70.00% of Group C, with a statistically significant difference (P<0.05). After treatment, the IPSS, QoL, TCM Syndrome Score, PV, and PVR of the 3 groups all decreased compared with those before treatment, while the Qmax value increased. Among them, the IPSS, QoL, TCM Syndrome Score, and PVR of Group A were lower than those of Groups B and C, and the Qmax value was higher than that of Groups B and C, with statistically significant differences (P<0.05). Conclusion: Wuling Powder combined with Tamsulosin Hydrochloride Sustained-Release Capsules has a significant efficacy in the treatment of BPH of Spleen-Kidney Yang Deficiency Type, which can provide a reference for the clinical treatment of this disease.

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