| 付心柔 李娅娅 李游 杨窑莉 魏国龙 江一平 许嵩 .基于炎癌转化探讨癌瘤外敷方联合定向透药治疗癌痛及对 IL-6、TNF-α 的影响[J].江西中医药大学学报,2025,37(5):25-28. |
| 基于炎癌转化探讨癌瘤外敷方联合定向透药治疗癌痛及对 IL-6、TNF-α 的影响 |
| Clinical Study on the Treatment of Cancer Pain and Its Effect on IL-6 and TNF-α Levels by External Application Formula of Cancer Combined with TCM Targeted Penetration Based on Inflammatory-Cancer Transformation |
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| DOI：10.20140/j.2095-7785.2025.05.08 |
| 中文关键词: 炎癌转化；中药；癌性疼痛；炎症因子；临床研究 |
| 英文关键词: Inflammatory-Cancer Transformation; Traditional Chinese Medicine; Cancer Pain; Inflammatory Cytokines; Clinical Research |
| 基金项目:江西省中医药管理局科技计划项目（2022A051）；江一平全国名老中医药专家传承工作室建设项目（国中医药人教函［2022］75 号） |
| 作者 | 单位 | | 付心柔 1 李娅娅 1 李游 1 杨窑莉 1 魏国龙 1 江一平 2 许嵩 2 | 1. 江西中医药大学附属洪都
中医院脾胃肝胆科 南昌 330006 ；2. 江西中医药大学附属医院脾胃科 南昌 330006 |
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| 中文摘要: |
| 目的：基于炎癌转化探讨癌瘤外敷方联合定向透药治疗癌痛的疗效及对血清 IL-6、TNF-α 水平的影响。方法：将
符合纳入标准的 60 例患者随机分为对照组及观察组，各 30 例。对照组予盐酸羟考酮缓释片口服，观察组在对照组基础上加
用癌瘤外敷方联合中医定向透药治疗，比较 2 组患者总有效率、止痛起效及持续时间、NRS 评分、QLQ-C30 生活质量评分
和血清 IL-6、TNF-α 水平变化。结果：治疗后对照组总有效率为 86.67%，观察组总有效率为 93.33%，差异有统计学意义
（P<0.05）；观察组的止痛起效时间与持续时间均优于对照组（P<0.05）；2 组患者治疗后 NRS 评分、QLQ-C30 生活质量评分
及血清 IL-6、TNF-α 水平均较治疗前改善（P<0.05），且改善程度观察组优于对照组（P<0.05）。结论：癌瘤外敷方联合中
医定向透药能有效缩短药物起效时间、延长持续时间，并能缓解患者腹痛症状、改善生活质量、降低血清 IL-6 和 TNF-α 水平。 |
| 英文摘要: |
| Objective: To investigate the efficacy of cancer external application formula combined with traditional Chinese medicine
targeted penetration in the treatment of cancer pain and the influence on serum levels of IL-6 and TNF-αbased on inflammatory-cancer
transformation. Methods: 60 patients meeting the criteria were randomly divided into control group and observation group, with 30 cases
in each group. The control group was given oxycodone hydrochloride sustained-release tablets orally, and the observation group was given
cancer tumor external application formula combined with TCM targeted penetration on the basis of the control group. The total effective rate,
analgesic onset and duration, NRS score, QLQ-C30 quality of life score and serum levels of IL-6 and TNF-α were compared between the
two groups. Results: After treatment, the total effective rate of the control group was 86.67%, while the observation group was 93.33%, the
difference was statistically significant (P<0.05). The analgesic onset time and duration in the observation group were better than those in the
control group (P<0.05). NRS score, QLQ-C30 quality of life score and serum levels of IL-6 and TNF-α in two groups were improved after
treatment (P<0.05), and the improvement of observation group was better than control group (P<0.05). Conclusion: Cancer tumor external
application formula combined with TCM targeted penetration can effectively shorten the time of drug onset, prolong the duration of drug,
effectively relieve the symptoms of abdominal pain, improve the quality of life, and reduce the serum levels of IL-6 and TNF-α. |
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