| 李红英 张兆英 胡杨 谢红英 李健萍.经验方治疗湿热下注证宫颈高危型人乳头瘤病毒感染的临床研究[J].江西中医药大学学报,2025,37(5):22-24/28. |
| 经验方治疗湿热下注证宫颈高危型人乳头瘤病毒感染的临床研究 |
| Clinical Research on the Treatment of Cervical High-risk Human Papillomavirus Infection with Damp-Heat Syndrome with Empirical Prescription |
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| DOI：10.20140/j.2095-7785.2025.05.07 |
| 中文关键词: 高危型人乳头瘤病毒；带下病；湿热下注证；经验方 |
| 英文关键词: High-risk Human Papillomavirus; Leukorrheal Disease; Damp-Heat Syndrome; Empirical Prescription |
| 基金项目:江西省中医药管理局科技计划项目（2023B1065）。 |
| 作者 | 单位 | | 李红英 张兆英 胡杨 谢红英 李健萍 | 赣州市中医院 江西 赣州 341000 |
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| 中文摘要: |
| 目的：探讨经验方治疗湿热下注证宫颈高危型人乳头瘤病毒（HPV）感染的临床效果。方法：选取 2021 年 10 月—
2023 年 11 月赣州市中医院收治的 HPV 感染患者 90 例，以随机数字表法分为对照组和观察组，各 45 例。对照组予重组人
干扰素 α2b 栓治疗，观察组在对照组的基础上，予经验方治疗。比较 2 组疗效、HPV 转阴率、中医证候积分、血清炎症因
子指标、免疫功能指标、不良反应及复发情况。结果：观察组总有效率、HPV 转阴率均较对照组高（P<0.05）；治疗后，观察
组中医证候积分、IL-6、IL-8、CD8+ 水平均较对照组低，CD4+
、IL-2 水平较均对照组高（P<0.05）；2 组间不良反应、复发
率比较，差异无统计学意义（P>0.05）。结论：经验方治疗湿热下注证宫颈 HPV 感染效果较好，可提高 HPV 转阴率，缓解临
床症状，减轻炎症反应，改善免疫指标，且安全性好。 |
| 英文摘要: |
| Objective: To investigate the clinical effect of empirical prescription in the treatment of cervical high-risk human papillomavirus
(HPV) infection with damp-heat syndrome. Methods: Ninety patients with high-risk HPV infection admitted to Ganzhou Hospital of Traditional
Chinese Medicine from October 2021 to November 2023 were divided into control group (45 cases) and observation group (45 cases) by random
number table method. The control group was treated with recombinant human interferon α2b supposit, and the observation group was treated
with empirical formula based on the control group. The efficacy, negative conversion rate of HPV, TCM syndrome score, serum inflammatory
factor index, immune function index, adverse reaction and recurrence were compared between the two groups. Results: The total effective
rate and negative conversion rate of HPV in the treatment group were higher than those in the control group (P<0.05). After treatment, TCM
syndrome score, IL-6, IL-8 and CD8+
levels in the treatment group were lower than those in the control group, and CD4+
and IL-2 levels were
higher than those in the control group (P<0.05). There was no significant difference in adverse reactions and recurrence rate between groups
(P>0.05). Conclusion: The empirical prescription is effective in the treatment of high risk cervical HPV infection with dampness and heat, can
improve the negative rate of high risk HPV, relieve clinical symptoms, reduce inflammation, improve immune indexes, and has good safety. |
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