| .柏益前列康对非细菌性前列腺炎大鼠 NF-кB 信号通路的
影响[J].江西中医药大学学报,2024,36(2):97-101. |
| 柏益前列康对非细菌性前列腺炎大鼠 NF-кB 信号通路的
影响 |
| Effect of Baiyi Qianliekang Granules on NF-кB Signaling Pathway in Nonbacterial Prostatitis Rats |
| |
| DOI：10.20140/j.2095-7785.2024.02.24 |
| 中文关键词: 柏益前列康颗粒；慢性非细菌性前列腺炎；炎症因子；NF-κB 信号通路 |
| 英文关键词: Baiyi Qianliekang Granule; Chronic Nonbacterial Prostatitis; Inflammatory Factors; NF-кB Signaling Pathway |
| 基金项目:陕西省重点研发计划项目（2022YWZX-03） |
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| 中文摘要: |
| 目的：探讨柏益前列康颗粒（BQG）对角叉菜胶所致慢性非细菌性前列腺炎大鼠 NF-κB 信号通路的影响。方法：1%
角叉菜胶复制慢性非细菌性前列腺炎大鼠模型，评估 BQG 对大鼠前列腺器官指数、组织病理形态以及大鼠前列腺组织中炎
症因子 IL-8、TNF-α 及 VEGF 表达水平的影响，Western blot 检测前列腺组织中 NF-κB 通路相关分子蛋白表达水平。结果：
BQG 可以降低前列腺器官指数，减轻前列腺组织内炎症反应。与模型组相比，BQG 显著降低前列腺组织中炎症因子 IL-8、
TNF-α、VEGF 表达水平及转录因子 p-IκKα、p-IκBα、NF-κBP65、p-NF-κBP65 蛋白表达水平（P<0.05）。结论：BQG
可抑制角叉菜胶所致大鼠慢性非细菌性前列腺炎，其作用机制可能与抑制 NF-кB 信号通路有关。 |
| 英文摘要: |
| Objective: To investigate the NF-кB signaling pathway in Baiyi Qianliekang granule (BQG) in nonbacterial prostatitis rats
induced by carrageenan. Methods: Chronic nonbacterial prostatitis rat model was induced by 1% carrageenan. The effects of BQG on
rat prostate organ index, histopathological morphology, as well as expression levels of inflammatory factors IL-8, TNF-α, VEGF in rat
prostate tissue were evaluated. Western blot was used to detect the expression of NF-κB pathway-related molecular proteins in rat prostate
tissues. Results: BQG could reduce prostate organ index and reduces inflammation in prostate tissue. Compared with the model group,
the expression levels of inflammatory factors IL-8, TNF-α, VEGF and the expression levels of transcription factors p-IκBα, p-IκKα,
NF-κBP65, p-NF-κBP65 in prostate tissue were significantly decreased (P＜0.05). Conclusion: BQG can inhibit chronic nonbacterial
prostatitis rats induced by carrageenan, and this effect may be related to inhibiting the activation of NF-кB signaling pathway. |
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